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Neuregulin 1 Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Neuregulin 1 in WB, IHC, ELISA, ICC und IF. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.
Produktnummer ABIN6254897

Kurzübersicht für Neuregulin 1 Antikörper (N-Term) (ABIN6254897)

Target

Alle Neuregulin 1 (NRG1) Antikörper anzeigen
Neuregulin 1 (NRG1)

Reaktivität

  • 112
  • 79
  • 51
  • 15
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 128
  • 20
Kaninchen

Klonalität

  • 127
  • 21
Polyklonal

Konjugat

  • 74
  • 14
  • 8
  • 6
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Neuregulin 1 Antikörper ist unkonjugiert

Applikation

  • 108
  • 55
  • 40
  • 39
  • 39
  • 38
  • 31
  • 24
  • 22
  • 11
  • 11
  • 6
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
  • Bindungsspezifität

    • 16
    • 16
    • 15
    • 10
    • 10
    • 9
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Spezifität

    NRG1 Antibody detects endogenous levels of total NRG1.

    Homologie

    Bovine,Horse,Rabbit,Dog

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human NRG1, corresponding to a region within N-terminal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    Neuregulin 1 (NRG1)

    Andere Bezeichnung

    NRG1

    Hintergrund

    Description: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells, inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction, stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells, stimulating Schwann cell proliferation, implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).

    Gene: NRG1

    Molekulargewicht

    44kDa

    Gen-ID

    3084

    UniProt

    Q02297

    Pathways

    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation
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