LHCGR Antikörper (N-Term)

Produktnummer ABIN6252071

Dieser Anti-LHCGR Antikörper ist ein Maus Monoklonal Antikörper zur Detektion von LHCGR in WB, IF, FACS und IHC (p). Geeignet für Human.

Kurzübersicht für LHCGR Antikörper (N-Term) (ABIN6252071)

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LHCGR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: LHCGR-1417

Produktdetails anti-LHCGR Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Protein G affinity chromatography

Immunogen: A partial recombinant protein from the N-terminal region of human Luteinizing hormone / Choriogonadotropin receptor was used as the immunogen for the LHR antibody.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml

IF: 1-2 μg/mL

IHC (FFPE): 0.5-1 μg/mL for 30 min at RT

Optimal dilution of the LHR antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Details zu LHCGR

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Andere Bezeichnung: hCG Receptor / LH Receptor

Hintergrund: Recognizes a protein of 78-85  kDa, which is identified as the receptor for Luteinizing hormone / Choriogonadotropin (LHR/CGR). Luteinizing hormone plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Choriogonadotropin production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone / choriogonadotropin receptor (LHCGR) as a seven transmembrane, G protein-coupled receptor glycoprotein. LHCGR influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of LHCGR on breast carcinoma correlates in part to the degree of tumor differentiation. LHCGR -positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women.

Gen-ID: 3973

UniProt: P22888

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, cAMP Metabolic Process, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling