ATG4D Antikörper (AA 326-356)

Produktnummer ABIN6244157

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ATG4D in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ATG4D Antikörper (AA 326-356) (ABIN6244157)

Target: ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG4D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB11866

Produktdetails anti-ATG4D Antikörper

Bindungsspezifität: AA 326-356

Homologie: M, Pig

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ATG4D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326~356 amino acids surrounding S341 of human APG4D.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu ATG4D

Target: ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

Andere Bezeichnung: ATG4D

Hintergrund: APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).

Molekulargewicht: 52922

NCBI Accession: NP_001268433, NP_116274

UniProt: Q86TL0

Pathways: Autophagie