DKK2 Antikörper
Kurzübersicht für DKK2 Antikörper (ABIN6244156)
Target
Alle DKK2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Aufreinigung
- This antibody is purified through a protein G column, followed by dialysis against PBS.
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Immunogen
- This DKK2 antibody is generated from a mouse immunized with a recombinant protein of human DKK2.
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Isotyp
- IgG1 kappa
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Applikationshinweise
- WB: 1:2000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Haltbarkeit
- 6 months
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- DKK2 (Dickkopf 2 Homolog (DKK2))
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Andere Bezeichnung
- DKK2
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Hintergrund
- Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
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Molekulargewicht
- 28447
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UniProt
- Q9UBU2
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Pathways
- WNT Signalweg
Target
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