SUFUH Antikörper (C-Term)

Produktnummer ABIN6244108

Dieses Anti-SUFUH-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SUFUH in WB. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für SUFUH Antikörper (C-Term) (ABIN6244108)

Target: SUFUH (Suppressor of Fused Homolog (SUFUH))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUFUH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB53250

Produktdetails anti-SUFUH Antikörper

Bindungsspezifität: AA 308-341, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SUFU antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 308-341 amino acids from the C-terminal region of human SUFU.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SUFUH Antikörper (ABIN6244108)

Wang, Li, Hu, Huang, Rao, Xiong, Luo, Lu, Luo: "Nek2A phosphorylates and stabilizes SuFu: A new strategy of Gli2/Hedgehog signaling regulatory mechanism." in: Cellular signalling, Vol. 28, Issue 9, pp. 1304-13, (2017) (PubMed).

Details zu SUFUH

Target: SUFUH (Suppressor of Fused Homolog (SUFUH))

Andere Bezeichnung: SUFU

Hintergrund: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU- GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).

Molekulargewicht: 53947

UniProt: Q9UMX1

Pathways: Hedgehog Signalweg, Tube Formation, Maintenance of Protein Location