SRGAP2 Antikörper (C-Term)

Produktnummer ABIN6244085

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SRGAP2 in WB. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für SRGAP2 Antikörper (C-Term) (ABIN6244085)

Target: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRGAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB53245

Produktdetails anti-SRGAP2 Antikörper

Bindungsspezifität: AA 1040-1071, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SRGAP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1040-1071amino acids from the C-terminal region of human SRGAP2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu SRGAP2

Target: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Andere Bezeichnung: SRGAP2

Hintergrund: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

Molekulargewicht: 120871

UniProt: O75044