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USP2 Antikörper (AA 1-258)

Der Maus Monoklonal Anti-USP2-Antikörper wurde für WB validiert. Er ist geeignet, USP2 in Proben von Human und Green Monkey zu detektieren.
Produktnummer ABIN6244029

Kurzübersicht für USP2 Antikörper (AA 1-258) (ABIN6244029)

Target

Alle USP2 Antikörper anzeigen
USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Reaktivität

  • 61
  • 10
  • 8
  • 6
  • 5
  • 5
  • 5
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Green Monkey

Wirt

  • 60
  • 3
Maus

Klonalität

  • 62
  • 1
Monoklonal

Konjugat

  • 35
  • 6
  • 5
  • 5
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser USP2 Antikörper ist unkonjugiert

Applikation

  • 45
  • 33
  • 27
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB)

Klon

1738CT331-50-87
  • Bindungsspezifität

    • 10
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-258

    Aufreinigung

    This antibody is purified through a protein G column, followed by dialysis against PBS.

    Immunogen

    This USP2 antibody is generated from a mouse immunized with a recombinant protein between 1-258 amino acids from human USP2.

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    WB: 1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Target

    USP2 (Ubiquitin Specific Peptidase 2 (USP2))

    Andere Bezeichnung

    USP2

    Hintergrund

    Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).

    Molekulargewicht

    68072

    UniProt

    O75604
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