USP2 Antikörper (AA 1-258)

Produktnummer ABIN6244029

Produktdetails anti-USP2 Antikörper

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Bindungsspezifität: AA 1-258

Reaktivität: Human, Green Monkey

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser USP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This USP2 antibody is generated from a mouse immunized with a recombinant protein between 1-258 amino acids from human USP2.

Klon: 1738CT331-50-87

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu USP2

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Andere Bezeichnung: USP2 (USP2 Produkte)

Hintergrund: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).

Molekulargewicht: 68072

UniProt: O75604