SNW1 Antikörper (AA 464-497)

Produktnummer ABIN6243922

Dieses Anti-SNW1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SNW1 in WB und IF. Geeignet für Human und Maus.

Kurzübersicht für SNW1 Antikörper (AA 464-497) (ABIN6243922)

Target: SNW1 (SNW Domain Containing 1 (SNW1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNW1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: RB54232

Produktdetails anti-SNW1 Antikörper

Bindungsspezifität: AA 464-497

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SNW1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 464-497 amino acids from human SNW1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu SNW1

Target: SNW1 (SNW Domain Containing 1 (SNW1))

Andere Bezeichnung: SNW1

Hintergrund: Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA, the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.

Molekulargewicht: 61494

UniProt: Q13573

Pathways: Retinoic Acid Receptor Signaling Pathway