EPH Receptor B3 Antikörper (AA 350-382)

Produktnummer ABIN6243857

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EPH Receptor B3 in WB. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für EPH Receptor B3 Antikörper (AA 350-382) (ABIN6243857)

Target: EPH Receptor B3 (EPHB3)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor B3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB50405

Produktdetails anti-EPH Receptor B3 Antikörper

Bindungsspezifität: AA 350-382

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Ephb3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 350-382 amino acids from the Central region of Mouse Ephb3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu EPH Receptor B3

Target: EPH Receptor B3 (EPHB3)

Andere Bezeichnung: Ephb3

Hintergrund: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.

Molekulargewicht: 109662

UniProt: P54754

Pathways: RTK Signalweg