MST1R Antikörper (AA 600-633)

Produktnummer ABIN6243848

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MST1R in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MST1R Antikörper (AA 600-633) (ABIN6243848)

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MST1R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB58004

Produktdetails anti-MST1R Antikörper

Bindungsspezifität: AA 600-633

Homologie: H

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MST1R antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 600-633 amino acids from the Central region of human MST1R.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu MST1R

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Andere Bezeichnung: MST1R

Hintergrund: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Molekulargewicht: 152241

UniProt: Q04912

Pathways: RTK Signalweg