Transferrin Receptor Antikörper (AA 649-677)
Kurzübersicht für Transferrin Receptor Antikörper (AA 649-677) (ABIN6243624)
Target
Alle Transferrin Receptor (TFRC) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 649-677
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Aufreinigung
- This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
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Immunogen
- This TFRC antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from human TFRC.
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Isotyp
- IgM
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Applikationshinweise
- WB: 1:1000. WB: 1:100~250
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Haltbarkeit
- 6 months
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- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
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Andere Bezeichnung
- TFRC
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Hintergrund
- Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
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Molekulargewicht
- 84871
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NCBI Accession
- NP_001121620, NP_003225
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UniProt
- P02786
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Pathways
- Transition Metal Ion Homeostasis
Target
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