Transferrin Receptor Antikörper (AA 649-677)

Produktnummer ABIN6243624

Der Maus Monoklonal Anti-Transferrin Receptor-Antikörper wurde für WB validiert. Er ist geeignet, Transferrin Receptor in Proben von Human zu detektieren.

Kurzübersicht für Transferrin Receptor Antikörper (AA 649-677) (ABIN6243624)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Transferrin Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 514CT23-4-1

Produktdetails anti-Transferrin Receptor Antikörper

Bindungsspezifität: AA 649-677

Aufreinigung: This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Immunogen: This TFRC antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from human TFRC.

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:100~250

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Andere Bezeichnung: TFRC

Hintergrund: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Molekulargewicht: 84871

NCBI Accession: NP_001121620, NP_003225

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis