FLT3 Antikörper (AA 474-510)

Produktnummer ABIN6243524

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FLT3 in WB. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für FLT3 Antikörper (AA 474-510) (ABIN6243524)

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FLT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB50841

Produktdetails anti-FLT3 Antikörper

Bindungsspezifität: AA 474-510

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FLT3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 474-510 amino acids from the Central region of human FLT3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu FLT3

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Andere Bezeichnung: FLT3

Hintergrund: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Molekulargewicht: 112903

UniProt: P36888

Pathways: RTK Signalweg