ALK Antikörper (C-Term)

Produktnummer ABIN6243476

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ALK in IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für ALK Antikörper (C-Term) (ABIN6243476)

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALK Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB1513-1514

Produktdetails anti-ALK Antikörper

Bindungsspezifität: AA 1591-1620, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ALK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1591~1620 amino acids from the C-terminal region of human ALK.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ALK Antikörper (ABIN6243476)

Liu, Mathialagan, Lappin, Fortner, Somps, Seitis, Johnson, Hu, Matsumoto: "Crizotinib reduces the rate of dark adaptation in the rat retina independent of ALK inhibition." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 143, Issue 1, pp. 116-25, (2016) (PubMed).

Details zu ALK

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Andere Bezeichnung: ALK

Hintergrund: ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2,5)(p23,q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.

Molekulargewicht: 176442

NCBI Accession: NP_004295

UniProt: Q9UM73

Pathways: RTK Signalweg