FER Antikörper

Produktnummer ABIN6243361

Dieses Anti-FER-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von FER in WB, IF und FACS. Geeignet für Maus.

Kurzübersicht für FER Antikörper (ABIN6243361)

Target: FER (FER Tyrosine Kinase (FER))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FER Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: 1487CT794-8-50

Produktdetails anti-FER Antikörper

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This Fer antibody is generated from a mouse immunized with a recombinant protein.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:4000. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu FER

Target: FER (FER Tyrosine Kinase (FER))

Andere Bezeichnung: Fer

Hintergrund: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3 according to PubMed:< a href="http://www.uniprot.org/citations/10878010" target="_blank">10878010 and PubMed:< a href="http://www.uniprot.org/citations/19159681" target="_blank">19159681, but clearly plays a redundant role in STAT3 phosphorylation. According to PubMed:< a href="http://www.uniprot.org/citations/11134346" target="_blank">11134346, cells where wild type FER has been replaced by a kinase-dead mutant show no reduction in STAT3 phosphorylation. Phosphorylates TMF1. Isoform 3 lacks kinase activity.

Molekulargewicht: 94579

UniProt: P70451