ULK3 Antikörper (C-Term)

Produktnummer ABIN6243328

Dieses Anti-ULK3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ULK3 in WB. Geeignet für Human, Maus und Ratte.

Kurzübersicht für ULK3 Antikörper (C-Term) (ABIN6243328)

Target: ULK3 (Unc-51-Like Kinase 3 (ULK3))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ULK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1404CT148-89-25

Produktdetails anti-ULK3 Antikörper

Bindungsspezifität: AA 435-468, C-Term

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This ULK3 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the C-terminal region of human ULK3.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: IHC: 1:50. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu ULK3

Target: ULK3 (Unc-51-Like Kinase 3 (ULK3))

Andere Bezeichnung: ULK3

Hintergrund: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.

Molekulargewicht: 53444

UniProt: Q6PHR2