GAB1 Antikörper

Produktnummer ABIN6243205

Zitiert in 2+ Publikationen. Der Maus Monoklonal anti-GAB1 Antikörper (Klon 1AT1979) (ABIN6243205) detektiert spezifisch GAB1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für GAB1 Antikörper (ABIN6243205)

Target: GAB1 (GRB2-Associated Binding Protein 1 (GAB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GAB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1AT1979

Produktdetails anti-GAB1 Antikörper

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This Gab1 antibody is generated from mice immunized with a GST fusion protein encoding full length human GAB1.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-GAB1 Antikörper (ABIN6243205)

Fan, Wong, Marino, Ou, Shen, Wu, Wong, Reiser, Johnson: "Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants." in: The Journal of biological chemistry, Vol. 288, Issue 23, pp. 16895-904, (2013) (PubMed).

Sun, Yuan, Liu, Shi, Baker, Vuori, Wu, Feng: "Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis." in: Molecular and cellular biology, Vol. 24, Issue 4, pp. 1531-9, (2004) (PubMed).

Details zu GAB1

Target: GAB1 (GRB2-Associated Binding Protein 1 (GAB1))

Andere Bezeichnung: Gab1

Hintergrund: The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 76616

NCBI Accession: NP_002030, NP_997006

UniProt: Q13480

Pathways: RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals