CXCL12 Antikörper
-
- Target Alle CXCL12 Antikörper anzeigen
- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
-
Reaktivität
- Human, Maus
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser CXCL12 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This Mouse Cxcl12 antibody is generated from a rabbit immunized with a Mouse Cxcl12 recombinant protein.
- Klon
- RB52661
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product CXCL12 Primärantikörper
-
-
- Applikationshinweise
- WB: 1:4000-1:8000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Haltbarkeit
- 6 months
-
- Target
- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
- Andere Bezeichnung
- Cxcl12 (CXCL12 Produkte)
- Synonyme
- IRH antikoerper, PBSF antikoerper, SCYB12 antikoerper, SDF1 antikoerper, TLSF antikoerper, TPAR1 antikoerper, CINC-1 antikoerper, Gro1 antikoerper, Pbsf antikoerper, Scyb12 antikoerper, Sdf1 antikoerper, Tlsf antikoerper, Tpar1 antikoerper, Fsp antikoerper, KC antikoerper, Mgsa antikoerper, N51 antikoerper, Scyb1 antikoerper, gro antikoerper, sdf-1 antikoerper, sdf1 antikoerper, xSDF-1 antikoerper, SDF-1 antikoerper, cxcl12 antikoerper, sdf-1a antikoerper, sdf1a antikoerper, wu:fa55e10 antikoerper, wu:fc16h12 antikoerper, wu:fj84c02 antikoerper, C-X-C motif chemokine ligand 12 antikoerper, C-X-C motif chemokine ligand 1 antikoerper, chemokine (C-X-C motif) ligand 12 antikoerper, chemokine (C-X-C motif) ligand 1 antikoerper, C-X-C motif chemokine ligand 12 L homeolog antikoerper, chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) antikoerper, CXCL12 antikoerper, cxcl12 antikoerper, Cxcl1 antikoerper, Cxcl12 antikoerper, cxcl12.L antikoerper, cxcl12a antikoerper
- Hintergrund
- Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
- Molekulargewicht
- 10561
- UniProt
- P40224
- Pathways
- Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
-