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MAP1LC3A Antikörper (AA 30-56)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAP1LC3A in WB, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.
Produktnummer ABIN6243032

Kurzübersicht für MAP1LC3A Antikörper (AA 30-56) (ABIN6243032)

Target

Alle MAP1LC3A Antikörper anzeigen
MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))

Reaktivität

  • 175
  • 102
  • 84
  • 11
  • 8
  • 5
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 144
  • 41
  • 2
Kaninchen

Klonalität

  • 131
  • 56
Polyklonal

Konjugat

  • 112
  • 12
  • 8
  • 8
  • 7
  • 6
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser MAP1LC3A Antikörper ist unkonjugiert

Applikation

  • 158
  • 72
  • 66
  • 34
  • 29
  • 29
  • 24
  • 21
  • 14
  • 12
  • 10
  • 5
  • 5
  • 5
  • 2
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB11840
  • Bindungsspezifität

    • 20
    • 15
    • 14
    • 11
    • 10
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 30-56

    Homologie

    Zf, B, M, Rat

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This LC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-56 amino acids from human LC3.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    IF: 1:100. WB: 1:1000. IHC-P: 1:10~50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Lu, Hsu: "Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii)." in: Age (Dordrecht, Netherlands), Vol. 37, Issue 2, pp. 33, (2015) (PubMed).

    Hsu, Chuang, Chan: "Changes in cellular degradation activity in young and old worker honeybees (Apis mellifera)." in: Experimental gerontology, Vol. 50, pp. 128-36, (2014) (PubMed).

  • Target

    MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))

    Andere Bezeichnung

    LC3

    Hintergrund

    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.

    NCBI Accession

    NP_115903, NP_852610

    UniProt

    Q9H492, Q9GZQ8

    Pathways

    Autophagie
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