STUB1 Antikörper

Produktnummer ABIN6242870

Dieser Maus Monoklonal Antikörper detektiert spezifisch STUB1 in WB. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für STUB1 Antikörper (ABIN6242870)

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STUB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1008CT12-4-1

Produktdetails anti-STUB1 Antikörper

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This STUB1 antibody is generated from a mouse immunized with a recombinant protein of human STUB1.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:4000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu STUB1

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Andere Bezeichnung: STUB1

Hintergrund: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.

Molekulargewicht: 34856

UniProt: Q9UNE7

Pathways: Regulation of Hormone Metabolic Process, Response to Water Deprivation