KCTD11 Antikörper (AA 21-53)

Produktnummer ABIN6242571

Der Kaninchen Polyklonal anti-KCTD11 Antikörper wird verwendet zum Nachweis von KCTD11 in Proben von Human und Maus. Er wurde validiert für WB und IHC (p).

Kurzübersicht für KCTD11 Antikörper (AA 21-53) (ABIN6242571)

Target: KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCTD11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB54391

Produktdetails anti-KCTD11 Antikörper

Bindungsspezifität: AA 21-53

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KCTD11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-53 amino acids from human KCTD11.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:2000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu KCTD11

Target: KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))

Andere Bezeichnung: KCTD11

Hintergrund: Plays a role as a marker and a regulator of neuronal differentiation, Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.

Molekulargewicht: 25887

UniProt: Q693B1

Pathways: Hedgehog Signalweg