BRD4 Antikörper (C-Term)

Produktnummer ABIN6242208

Der Kaninchen Polyklonal Anti-BRD4-Antikörper wurde für IHC (p) validiert. Er ist geeignet, BRD4 in Proben von Human zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für BRD4 Antikörper (C-Term) (ABIN6242208)

Target: BRD4 (Bromodomain Containing 4 (BRD4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRD4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB3422

Produktdetails anti-BRD4 Antikörper

Bindungsspezifität: AA 1313-1342, C-Term

Homologie: M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BRD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1313~1342 amino acids from the C-terminal region of human BRD4.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IHC-P: 1:50~100. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-BRD4 Antikörper (ABIN6242208)

Yamada, Honma, Mochizuki, Goda: "BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver." in: Metabolism: clinical and experimental, Vol. 65, Issue 10, pp. 1478-88, (2017) (PubMed).

Sénéchal, Poirier, Coulombe, Laimins, Archambault: "Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4." in: Virology, Vol. 358, Issue 1, pp. 10-7, (2007) (PubMed).

Kurg, Tekkel, Abroi, Ustav: "Characterization of the functional activities of the bovine papillomavirus type 1 E2 protein single-chain heterodimers." in: Journal of virology, Vol. 80, Issue 22, pp. 11218-25, (2006) (PubMed).

Kurg, Sild, Ilves, Sepp, Ustav: "Association of bovine papillomavirus E2 protein with nuclear structures in vivo." in: Journal of virology, Vol. 79, Issue 16, pp. 10528-39, (2005) (PubMed).

Details zu BRD4

Target: BRD4 (Bromodomain Containing 4 (BRD4))

Andere Bezeichnung: BRD4

Hintergrund: BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. The gene has been implicated as the chromosome 19 target of translocation t(15,19)(q13,p13.1), which defines an upper respiratory tract carcinoma in young people.

Molekulargewicht: 152219

NCBI Accession: NP_055114, NP_490597

UniProt: O60885

Pathways: Chromatin Binding, SARS-CoV-2 Protein Interaktom