NEIL3 Antikörper

Produktnummer ABIN6241838

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NEIL3 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für NEIL3 Antikörper (ABIN6241838)

Target: NEIL3 (Nei Endonuclease VIII-Like 3 (NEIL3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NEIL3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NEIL3 Antikörper

Immunogen: synthetic peptide

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C,-20 °C

Details zu NEIL3

Target: NEIL3 (Nei Endonuclease VIII-Like 3 (NEIL3))

Andere Bezeichnung: NEIL3

Hintergrund: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA, also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5- OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.

UniProt: Q8TAT5

Pathways: DNA Reparatur