H2AFX
Reaktivität: Human
WB, IF, ICC
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
WB: 1:2000. ICC: 1:400
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Lagerung
4 °C,-20 °C
Target
H2AFX
(H2A Histone Family, Member X (H2AFX))
Andere Bezeichnung
Histone H2A.X
Hintergrund
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.