NKX2-1 Antikörper (CF®647)
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- Target Alle NKX2-1 Antikörper anzeigen
- NKX2-1 (NK2 Homeobox 1 (NKX2-1))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser NKX2-1 Antikörper ist konjugiert mit CF®647
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Applikation
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Verwendungszweck
- Mouse Monoclonal anti-TTF-1 / NKX2.1 (8G7G3/1 + NX2.1/690), CF647 Conjugate
- Produktmerkmale
- This antibody recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies. Primary antibodies are available purified, or with a selection of fluorescent CF ® dyes and other labels. CF ® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF ®405S and CF ®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogen
- Rat full length TTF-1 recombinant protein (8G7G3/1), Recombinant TTF-1 protein (NX2.1/690)
- Klon
- 8G7G3-1 NX2-1-690
- Isotyp
- IgG
- Top Product
- Discover our top product NKX2-1 Primärantikörper
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- Applikationshinweise
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Immunohistology formalin-fixed 0.5-1 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
- Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Optimal dilution for a specific application should be determined by user
- Kommentare
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MAD109, MLE-15, H441-4, or H345 cells. Normal thyroid or lung.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Protect from light
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- Target
- NKX2-1 (NK2 Homeobox 1 (NKX2-1))
- Andere Bezeichnung
- TTF-1 / NKX2.1 (NKX2-1 Produkte)
- Synonyme
- BCH antikoerper, BHC antikoerper, NK-2 antikoerper, NKX2.1 antikoerper, NKX2A antikoerper, TEBP antikoerper, TITF1 antikoerper, TTF-1 antikoerper, TTF1 antikoerper, titf1-A antikoerper, Xnkx-2.1 antikoerper, NKX2-1 antikoerper, LOC100227803 antikoerper, AV026640 antikoerper, Nkx2.1 antikoerper, T/EBP antikoerper, Titf1 antikoerper, Ttf-1 antikoerper, nk2.1a antikoerper, nkx2.1 antikoerper, nkx2.4a antikoerper, titf1 antikoerper, titf1a antikoerper, NK2 homeobox 1 antikoerper, NK2 homeobox 1 L homeolog antikoerper, NK2 homeobox 4b antikoerper, NKX2-1 antikoerper, nkx2-1.L antikoerper, Nkx2-1 antikoerper, nkx2.4b antikoerper
- Hintergrund
- BCH|Benign chorea|BHC|Homeobox protein Nkx2.1|NK2 homeobox 1|NKX2.1|NKX2A|TEBP|Thyroid nuclear factor-1|Thyroid specific enhancer binding protein|Thyroid transcription factor-1 (TTF-1)|Tin man|TITF1|TTF-1
- Molekulargewicht
- 40 kDa
- Gen-ID
- 7080, 94367
- UniProt
- P43699
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour
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