Serotonin Receptor 1A Antikörper (AA 294-312)

Produktnummer ABIN617930

Der Kaninchen Polyklonal Anti-Serotonin Receptor 1A-Antikörper wurde für IHC, IF, ICC und IEM validiert. Er ist geeignet, Serotonin Receptor 1A in Proben von Human, Ratte, Maus, Affe und Meerschweinchen zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für Serotonin Receptor 1A Antikörper (AA 294-312) (ABIN617930)

Target: Serotonin Receptor 1A (HTR1A)

Reaktivität: Human, Ratte, Maus, Affe, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Serotonin Receptor 1A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoelectron Microscopy (IEM)

Produktdetails anti-Serotonin Receptor 1A Antikörper

Bindungsspezifität: AA 294-312

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Produktmerkmale: The 5-HT 1A Receptor Antibody was raised against synthetic peptide sequence corresponding to amino acids 294-312 of the rat 5-HT1A receptor. The antiserum is provided as 100 μL of affinity purified serum containing 1 % BSA. The antiserum demonstrates strongly positive labeling of rat cortex, arcuate and hippocampus using indirect immunofluorescent and biotin/avidin-HRP techniques. Recommended primary dilutions are 1/100 - 1/200 in PBS - Bn/Av-HRP detection. Intensification methods such as nickel will approximately double the dilution factor as recommended. The antibody was characterized by immunohistochemistry and Western blot. Western blot showed a single band of approximately 45 kD. Preincubation of the antibody with an excess of the synthetic peptide blocked staining. Immunohistochemical staining of rat brain correlates well with Northern analysis, in situ hybridization and receptor autoradiography. BlastP database sequence homology searches confirmed that this sequence is unique to rat, mouse and human 5-HT1A receptors.

Aufreinigung: Affinity Purified

Immunogen: Rat 5-HT1A receptor (294-312)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Contains ≤ 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: After reconstitution, use immediately or refrigerate at 2 - 8 °C up to 2 days. For long-term storage aliquot antibody and freeze at -15 °C or lower. Avoid repeated freeze/thaw cycles.

Referenzen für anti-Serotonin Receptor 1A Antikörper (ABIN617930)

Lee, Ahn, Won: "New expression of 5-HT1A receptor in astrocytes in the gerbil hippocampal CA1 region following transient global cerebral ischemia." in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, Vol. 36, Issue 3, pp. 383-9, (2016) (PubMed).

Wang, Wang, Zou, Qu, Liu, Fei, Xia, Needleman, Mikami, Wood: "Mast cell expression of the serotonin1A receptor in guinea pig and human intestine." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 304, Issue 10, pp. G855-63, (2013) (PubMed).

Ahn, Balaban: "Distribution of 5-HT1B and 5-HT1D receptors in the inner ear." in: Brain research, Vol. 1346, pp. 92-101, (2010) (PubMed).

Hadjighassem, Austin, Szewczyk, Daigle, Stockmeier, Albert: "Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression." in: Biological psychiatry, Vol. 66, Issue 3, pp. 214-22, (2009) (PubMed).

Chalazonitis, Pham, Li, Roman, Guha, Gomes, Kan, Kessler, Gershon: "Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit." in: The Journal of comparative neurology, Vol. 509, Issue 5, pp. 474-92, (2008) (PubMed).

Details zu Serotonin Receptor 1A

Target: Serotonin Receptor 1A (HTR1A)

Hintergrund: Other Names:
5-hydroxytryptamine receptor 1A, ADRB2RL1, ADRBRL1,RAT5HT1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled

Gen-ID: 24473

Pathways: JAK-STAT Signalweg, Synaptic Membrane, Feeding Behaviour