CTNND1 Antikörper (pTyr96) (Biotin)

Produktnummer ABIN6178393

Produktdetails anti-CTNND1 Antikörper (Biotin)

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Bindungsspezifität: pTyr96

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CTNND1 Antikörper ist konjugiert mit Biotin

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS)

Verwendungszweck: Mouse Monoclonal anti-Catenin, delta-1 (25a), Biotin Conjugate

Produktmerkmale: The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Mouse p120 Catenin (pY96)

Klon: 25a

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow Cytometry 0.5-1 μg/million cells/0.1 mL

• Immunofluorescence 1-2 μg/mL
• Optimal dilution for a specific application should be determined by user

Kommentare:

Carcinoma

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu CTNND1

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Andere Bezeichnung: Catenin, delta-1 (CTNND1 Produkte)

Synonyme: CAS antikoerper, CTNND antikoerper, P120CAS antikoerper, P120CTN antikoerper, p120 antikoerper, p120(CAS) antikoerper, p120(CTN) antikoerper, Catns antikoerper, cas antikoerper, Xp120 antikoerper, ctnnd antikoerper, p120cas antikoerper, p120ctn antikoerper, p120(ctn) antikoerper, Xp120(ctn) antikoerper, p120-catenin antikoerper, CTNND1 antikoerper, AA409437 antikoerper, AU019353 antikoerper, Ctnnd antikoerper, P120 antikoerper, mKIAA0384 antikoerper, catenin delta 1 antikoerper, catenin (cadherin-associated protein), delta 1 antikoerper, catenin (cadherin associated protein), delta 1 antikoerper, catenin delta 1 L homeolog antikoerper, CTNND1 antikoerper, Ctnnd1 antikoerper, ctnnd1 antikoerper, ctnnd1.L antikoerper

Hintergrund: Cadherin-associated Src substrate (CAS), Catenin (cadherin associated protein) delta 1, Catenin delta-1, CTNND1, p120 catenin, P120 CTN, p120(cas), p120(ctn), P120CAS, P120CTN

Molekulargewicht: 120 kDa

Gen-ID: 1500

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling