Desmoglein 2 Antikörper (CF®488A)

Produktnummer ABIN6162215

Dieses Anti-Desmoglein 2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Desmoglein 2 in WB, IF und FACS. Geeignet für Human.

Kurzübersicht für Desmoglein 2 Antikörper (CF®488A) (ABIN6162215)

Target: Desmoglein 2 (DSG2)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Desmoglein 2 Antikörper ist konjugiert mit CF®488A

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: 6D8

Produktdetails anti-Desmoglein 2 Antikörper (CF®488A)

Verwendungszweck: Mouse Monoclonal anti-Desmoglein-2 (6D8), CF488A Conjugate

Produktmerkmale: This antibody recognizes the extracellular domain of human desmoglein-2 (DSG2), a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Human Desmoglein-2 is a type I transmembrane glycoprotein of 1117 amino acid (aa) residues with a 23 aa signal peptide and a 25 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. Desmoglein-2 has been shown to be important in establishing cell-cell adhesion and function in epithelial cells. It was originally identified in colon carcinoma and colon, and was named HDGC (human desmoglein colon). Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human full-length DSG2 protein

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow Cytometry 0.5-1 μg/million cells/0.1 mL

• Immunofluorescence 1-2 μg/mL
• Western blotting 0.5-1 μg/mL
• Optimal dilution for a specific application should be determined by user

Kommentare:

A431, HepG2 or K562 cells. Heart or Colon

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Details zu Desmoglein 2

Target: Desmoglein 2 (DSG2)

Andere Bezeichnung: Desmoglein-2

Hintergrund: ARVC10, ARVD10, Cadherin family member 5, CDHF5, CMD1BB, Desmoglein-2, DSG2, HDGC, Human Desmoglein Colon

Molekulargewicht: ~165 kDa

Gen-ID: 1829, 412597

UniProt: Q14126

Pathways: Cell-Cell Junction Organization