Integrin beta 4 Antikörper (Biotin)

Produktnummer ABIN6157662

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Integrin beta 4 in FACS, IF und BR. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Integrin beta 4 Antikörper (Biotin) (ABIN6157662)

Target: Integrin beta 4 (ITGB4)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 4 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Blocking Reagent (BR)

Klon: UM-A9

Produktdetails anti-Integrin beta 4 Antikörper (Biotin)

Verwendungszweck: Mouse Monoclonal anti-CD104 (UM-A9), Biotin Conjugate

Produktmerkmale: This antibody recognizes a protein of 205 kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Human squamous cell carcinoma (UM-SCC1)

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Biological blockade partially blocks laminin binding

• Immunofluorescence 0.5-1 μg/mL
• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Optimal dilution for a specific application should be determined by user

Kommentare:

A431 cells, squamous cell carcinoma, colon or placenta

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu Integrin beta 4

Target: Integrin beta 4 (ITGB4)

Andere Bezeichnung: CD104

Hintergrund: GP150, Integrin beta-4, ITGB4

Molekulargewicht: 205 kDa

Gen-ID: 3691, 632226

UniProt: P16144

Pathways: Integrin Complex