OPTN Antikörper (AA 575-591)

Produktnummer ABIN615041

Der Kaninchen Polyklonal Anti-OPTN-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, OPTN in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für OPTN Antikörper (AA 575-591) (ABIN615041)

Target: OPTN (Optineurin (OPTN))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OPTN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-OPTN Antikörper

Bindungsspezifität: AA 575-591

Spezifität: This antibody reacts to Optineurin (OPTN).

Aufreinigung: Immunoaffinity Chromatography

Immunogen: OPTN antibody was raised against synthetic peptide corresponding to aa 575-591 (G575EVLPDIDTLQIHVMDC591) of human, mouse and rat optineurin (FIP-2 (14.7K interacting protein-2), NRP (nemo-related protein)). Genename: OPTN

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: TBS, pH 7.4 containing 0.5 mg/mL BSA, 0.02 % sodium azide, 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu OPTN

Target: OPTN (Optineurin (OPTN))

Andere Bezeichnung: Optineurin / HIP7

Hintergrund: Optineurin (OTPN), a coiled-coil containing protein, may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins.Synonyms: E3-14.7K-interacting protein, FIP-2, FIP2, GLC1E, HYPL, Huntingtin yeast partner L, Huntingtin-interacting protein 7, Huntingtin-interacting protein L, NEMO-related protein, NRP, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein

Gen-ID: 10133

NCBI Accession: NP_001008212

UniProt: Q96CV9

Pathways: M Phase