Vitamin D Receptor Antikörper (AA 128-427)

Produktnummer ABIN6150080

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Vitamin D Receptor in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Vitamin D Receptor Antikörper (AA 128-427) (ABIN6150080)

Target: Vitamin D Receptor (VDR)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Vitamin D Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Vitamin D Receptor Antikörper

Bindungsspezifität: AA 128-427

Sequenz: QQRIIAILLD AHHKTYDPTY SDFCQFRPPV RVNDGGGSHP SRPNSRHTPS FSGDSSSSCS DHCITSSDMM DSSSFSNLDL SEEDSDDPSV TLELSQLSML PHLADLVSYS IQKVIGFAKM IPGFRDLTSE DQIVLLKSSA IEVIMLRSNE SFTMDDMSWT CGNQDYKYRV SDVTKAGHSL ELIEPLIKFQ VGLKKLNLHE EEHVLLMAIC IVSPDRPGVQ DAALIEAIQD RLSNTLQTYI RCRHPPPGSH LLYAKMIQKL ADLRSLNEEH SKQYRCLSFQ PECSMKLTPL VLEVFGNEIS

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 128-427 of human VDR (NP_000367.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Vitamin D Receptor

Target: Vitamin D Receptor (VDR)

Andere Bezeichnung: VDR

Substanzklasse: Chemical

Hintergrund: This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.,VDR,NR1I1,PPP1R163,Epigenetics & Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Nuclear hormone receptors,Cancer,Signal Transduction,VDR

Molekulargewicht: 48 kDa/53 kDa

Gen-ID: 7421

UniProt: P11473

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway