TP53INP1 Antikörper (AA 1-100)

Produktnummer ABIN6149422

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TP53INP1 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TP53INP1 Antikörper (AA 1-100) (ABIN6149422)

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TP53INP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TP53INP1 Antikörper

Bindungsspezifität: AA 1-100

Sequenz: MFQRLNKMFV GEVSSSSNQE PEFNEKEDDE WILVDFIDTC TGFSAEEEEE EEDISEESPT EHPSVFSCLP ASLECLADTS DSCFLQFESC PMEESWFITP

Kreuzreaktivität: Maus

Produktmerkmale: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human p53 DINP1 (NP_001129205.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TP53INP1

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Andere Bezeichnung: TP53INP1

Hintergrund: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.,TP53INP1,SIP,TP53DINP1,TP53INP1A,TP53INP1B,Teap,p53DINP1,Cancer,Tumor suppressors,p53 pathway,Cell Biology & Developmental Biology,Apoptosis,Autophagy,TP53INP1

Molekulargewicht: 18 kDa/27 kDa

Gen-ID: 94241

UniProt: Q96A56