STRA13 Antikörper (AA 1-63)

Produktnummer ABIN6148631

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch STRA13 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für STRA13 Antikörper (AA 1-63) (ABIN6148631)

Target: STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STRA13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-STRA13 Antikörper

Bindungsspezifität: AA 1-63

Sequenz: MEGAGAGSGF RKELVSRLLH LHFKDDKTKE AAVRGVRQAQ AEDALRVDVD QLEKVLPQLL LDF

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-63 of human STRA13 (NP_659435.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu STRA13

Target: STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))

Andere Bezeichnung: STRA13

Hintergrund: DNA-binding component of the Fanconi anemia (FA core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer, crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins, rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer, involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own.,CENPX,CENP-X,D9,FAAP10,MHF2,STRA13,Epigenetics & Nuclear Signaling,DNA Damage & Repair,STRA13

Molekulargewicht: 6 kDa/7 kDa/8 kDa

Gen-ID: 201254

UniProt: A8MT69