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STRA13 Antikörper

STRA13 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7264936
  • Target Alle STRA13 Antikörper anzeigen
    STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
    Reaktivität
    Human
    Wirt
    • 6
    Kaninchen
    Klonalität
    • 6
    Polyklonal
    Konjugat
    • 3
    • 1
    • 1
    • 1
    Dieser STRA13 Antikörper ist unkonjugiert
    Applikation
    • 4
    • 2
    • 1
    Western Blotting (WB)
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein of human STRA13 (NP_659435.2).
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
    Andere Bezeichnung
    STRA13 (STRA13 Produkte)
    Synonyme
    CENP-X antikoerper, CENPX antikoerper, D9 antikoerper, FAAP10 antikoerper, MHF2 antikoerper, BHLHB2 antikoerper, centromere protein X antikoerper, CENPX antikoerper, Cenpx antikoerper
    Hintergrund
    DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.
    Molekulargewicht

    Observed_MW: 14 kDa

    Calculated_MW: 6 kDa/7 kDa/8 kDa

    Gen-ID
    201254
    UniProt
    A8MT69
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