beta Amyloid Antikörper (C-Term) (Biotin)

Produktnummer ABIN614820

Der Biotin-konjugierte Maus Monoklonal anti-beta Amyloid Antikörper (ABIN614820) detektiert spezifisch beta Amyloid in EIA und ELISA (Detection). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für beta Amyloid Antikörper (C-Term) (Biotin) (ABIN614820)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Amyloid Antikörper ist konjugiert mit Biotin

Applikation: Enzyme Immunoassay (EIA), ELISA (Detection)

Produktdetails anti-beta Amyloid Antikörper (Biotin)

Bindungsspezifität: C-Term

Sequenz: MVGGVVIA

Spezifität: This antibody recognizes the C-terminal sequence (MVGGVVIA) of Aβ42 and full length Aβ42. The antibody does not cross react with amyloid beta peptide 40 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is less than 1 % in ELISA.

Kreuzreaktivität (Details): Species reactivity (tested):Human and other primates, Mouse, Rat.

Aufreinigung: Protein G affinity chromatography

Immunogen: C-terminal of human beta amyloid peptide 42, conjugated with KLH

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M PBS, pH 7.0 ± 0.1, 0.1 % Proclin-300, 1 % Gelatin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Amyloid beta

Hintergrund: Amyloid beta peptide 42 (Aβ42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Aβ42 and Aβ40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Aβ42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Aβ42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Aβ42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of Aβ42 oligomer is the cause of the disease.

Gen-ID: 351

Pathways: Inflammasome