beta Amyloid Antikörper (C-Term) (Biotin)

Produktnummer ABIN614816

Der Maus Monoklonal Anti-beta Amyloid-Antikörper wurde für EIA und ELISA (Detection) validiert. Er ist geeignet, beta Amyloid in Proben von Human zu detektieren.

Kurzübersicht für beta Amyloid Antikörper (C-Term) (Biotin) (ABIN614816)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Amyloid Antikörper ist konjugiert mit Biotin

Applikation: Enzyme Immunoassay (EIA), ELISA (Detection)

Klon: CV9 7B10

Produktdetails anti-beta Amyloid Antikörper (Biotin)

Bindungsspezifität: C-Term

Sequenz: GLMVGGVV

Spezifität: This antibody recognizes the C-terminal sequence (MVGGVVIA) of Aβ40 and full length Aβ40. The antibody does not cross react with amyloid beta peptide 42 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is less than 1 % in ELISA.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Protein G affinity chromatohraphy

Immunogen: C-terminal amino acid sequence of human beta amyloid peptide 40, conjugated with KLH

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M PBS, pH 7.0 ± 0.1, 0.1 % Proclin-300, 1 % gelatin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Amyloid beta

Hintergrund: Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

Gen-ID: 351

Pathways: Inflammasome