SIRPA Antikörper (AA 395-504)

Produktnummer ABIN6147780

Dieses Anti-SIRPA-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SIRPA in WB und IF. Geeignet für Human.

Kurzübersicht für SIRPA Antikörper (AA 395-504) (ABIN6147780)

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRPA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-SIRPA Antikörper

Bindungsspezifität: AA 395-504

Sequenz: RIRQKKAQGS TSSTRLHEPE KNAREITQDT NDITYADLNL PKGKKPAPQA AEPNNHTEYA SIQTSPQPAS EDTLTYADLD MVHLNRTPKQ PAPKPEPSFS EYASVQVPRK

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 395-504 of human CD172a/SIRPalpha (NP_542970.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Andere Bezeichnung: SIRPA

Hintergrund: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.,SIRPA,BIT,CD172A,MFR,MYD-1,P84,PTPNS1,SHPS1,SIRP,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Immunology & Inflammation,CD markers,Neuroscience,Cell Type Marker,Cardiovascular,Neuron marker,Synapse marker,SIRPA

Molekulargewicht: 54 kDa/55 kDa

Gen-ID: 140885

UniProt: P78324