CD180 Antikörper

Produktnummer ABIN614758

Produktdetails anti-CD180 Antikörper

Target: CD180 (CD180 Molecule (CD180))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD180 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Spezifität: This antibody detects CD180.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein-A affinity chromatography

Reinheit: > 95 % pure by SDS-PAGE

Immunogen: Human tonsillar B cells

Klon: G28-8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS with 15 mM sodium azide, approx. pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu CD180

Target: CD180 (CD180 Molecule (CD180))

Andere Bezeichnung: CD180 / RP105 (CD180 Produkte)

Synonyme: Ly78 antikoerper, CD180 antikoerper, LY64 antikoerper, RP105 antikoerper, F630107B15 antikoerper, CD180 molecule antikoerper, CD180 antigen antikoerper, Cd180 antikoerper, CD180 antikoerper

Hintergrund: CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.Synonyms: LY64, Lymphocyte antigen 64, Radioprotective 105 kDa protein

Gen-ID: 4064

NCBI Accession: NP_005573

UniProt: Q99467

Pathways: Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades