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CD180 Antikörper

CD180 Reaktivität: Human FACS, IP, Func Wirt: Maus Monoclonal G28-8 unconjugated
Produktnummer ABIN2749219
  • Target Alle CD180 Antikörper anzeigen
    CD180 (CD180 Molecule (CD180))
    Reaktivität
    • 20
    • 13
    • 3
    • 1
    Human
    Wirt
    • 12
    • 8
    • 6
    Maus
    Klonalität
    • 14
    • 12
    Monoklonal
    Konjugat
    • 18
    • 4
    • 2
    • 1
    • 1
    Dieser CD180 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 13
    • 8
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
    Spezifität
    The mouse monoclonal antibody G28-8 recognizes an extracellular epitope of CD180, a 95-105 kDa TLR-like glycoprotein expressed on peripheral blood monocytes and dendritic cells, mantle zone B cells and marginal zone B cells, but very weakly on germinal center B cells.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Endotoxin-Niveau
    Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
    Immunogen
    Human tonsillar B cells
    Klon
    G28-8
    Isotyp
    IgG1 kappa
  • Applikationshinweise
    Functional application: Induction of B cell proliferation.
    Flow cytometry: Recommended dilution: 2 μg/mL.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4
    Konservierungsmittel
    Azide free
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Olson, Graves, Shu, Ryan, Clark: "Caspase activity is required for stimulated B lymphocytes to enter the cell cycle." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 6065-72, (2003) (PubMed).

    Clark, Shu, Lüscher, Draves, Banchereau, Ledbetter, Valentine: "Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 143, Issue 12, pp. 3873-80, (1990) (PubMed).

    Valentine, Clark, Shu, Norris, Ledbetter: "Antibody to a novel 95-kDa surface glycoprotein on human B cells induces calcium mobilization and B cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 12, pp. 4071-8, (1988) (PubMed).

  • Target
    CD180 (CD180 Molecule (CD180))
    Andere Bezeichnung
    CD180 (CD180 Produkte)
    Synonyme
    Ly78 antikoerper, CD180 antikoerper, LY64 antikoerper, RP105 antikoerper, F630107B15 antikoerper, CD180 molecule antikoerper, CD180 antigen antikoerper, Cd180 antikoerper, CD180 antikoerper
    Hintergrund
    CD180 Molecule,CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1, and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.,LY64, Ly78, RP105, Bgp95
    Gen-ID
    4064
    UniProt
    Q99467
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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