vdrbeta antikoerper, vdr0 antikoerper, LOC100136219 antikoerper, NR1I1-B antikoerper, gb:dq017633 antikoerper, vdr-b antikoerper, Ci-VDR-b antikoerper, VDR antikoerper, LOC100221284 antikoerper, vdr-A antikoerper, xVDR antikoerper, Nr1i1 antikoerper, vdr antikoerper, NR1I1 antikoerper, PPP1R163 antikoerper, vitamin D (1,25- dihydroxyvitamin D3) receptor antikoerper, vitamin D receptor antikoerper, vitamin D3 receptor A antikoerper, vitamin D receptor b antikoerper, nuclear receptor VDR-b antikoerper, vitamin D (1,25- dihydroxyvitamin D3) receptor L homeolog antikoerper, vitamin D (1,25-dihydroxyvitamin D3) receptor antikoerper, vitamin D receptor a antikoerper, vdr antikoerper, vdr0 antikoerper, VDR antikoerper, LOC100136219 antikoerper, vdrb antikoerper, vdr-b antikoerper, vdr.L antikoerper, Vdr antikoerper, vdra antikoerper
Substanzklasse
Chemical
Hintergrund
The vitamin D receptor, a NR1 Thyroid Hormone-Like Receptor, is activated by calcitriol, the active hormonal form of vitamin D. The activated receptor binds DNA at a specific vitamin D-responsive element and promotes transcription of vitamin D target genes such as osteocalcin, the most abundant noncollagenous protein in bone. The vitamin D receptor affects growth, bone formation, and female reproduction. For example, this receptor modulates the growth and differentiation of keratinocytes and mediates the beneficial effects of vitamin D on psoriatic skin. It also inhibits hormone secretion by and proliferation of parathyroid cells. The vitamin D receptor functions either as a homodimer or as a heterodimer of vitamin D and retinoid acid X receptor subunits. Inactivation of the receptor leads to hypocalcemia and Rickets-alopecia syndrome. Recently, the vitamin D receptor has been shown to function as a receptor for the secondary bile acid lithocholic acid (LCA), which is hepatotoxic and a potential enteric carcinogen. Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine. An alternatively spliced vitamin D receptor that has an altered ligand-binding domain has been isolated from rats.Synonyms: 1, 25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR