Vitamin D Receptor Antikörper (AA 1-428)

Produktnummer ABIN614675

Der Maus Monoklonal Anti-Vitamin D Receptor-Antikörper wurde für IHC (p) und EIA validiert. Er ist geeignet, Vitamin D Receptor in Proben von Human zu detektieren.

Kurzübersicht für Vitamin D Receptor Antikörper (AA 1-428) (ABIN614675)

Target: Vitamin D Receptor (VDR)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Vitamin D Receptor Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Klon: 2F4

Produktdetails anti-Vitamin D Receptor Antikörper

Bindungsspezifität: AA 1-428

Spezifität: This antibody reacts to Vitamin D Receptor (VDR).

Aufreinigung: Protein A Chromatography

Immunogen: Recombinant protein, VDR (AAH60832, 1 a.a. ~ 428 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Genename: VDR

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,5 mg/mL

Buffer: PBS, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu Vitamin D Receptor

Target: Vitamin D Receptor (VDR)

Andere Bezeichnung: Vitamin D3 Receptor / NR1I1

Substanzklasse: Chemical

Hintergrund: The vitamin D receptor, a NR1 Thyroid Hormone-Like Receptor, is activated by calcitriol, the active hormonal form of vitamin D. The activated receptor binds DNA at a specific vitamin D-responsive element and promotes transcription of vitamin D target genes such as osteocalcin, the most abundant noncollagenous protein in bone. The vitamin D receptor affects growth, bone formation, and female reproduction. For example, this receptor modulates the growth and differentiation of keratinocytes and mediates the beneficial effects of vitamin D on psoriatic skin. It also inhibits hormone secretion by and proliferation of parathyroid cells. The vitamin D receptor functions either as a homodimer or as a heterodimer of vitamin D and retinoid acid X receptor subunits. Inactivation of the receptor leads to hypocalcemia and Rickets-alopecia syndrome. Recently, the vitamin D receptor has been shown to function as a receptor for the secondary bile acid lithocholic acid (LCA), which is hepatotoxic and a potential enteric carcinogen. Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine. An alternatively spliced vitamin D receptor that has an altered ligand-binding domain has been isolated from rats.Synonyms: 1, 25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR

Gen-ID: 7421

NCBI Accession: NP_000367

UniProt: P11473

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway