NEDD4-2 Antikörper (AA 836-955)
Kurzübersicht für NEDD4-2 Antikörper (AA 836-955) (ABIN6144504)
Target
Alle NEDD4-2 (NEDD4L) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 836-955
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Sequenz
- GDVDVNDWRQ HSIYKNGYCP NHPVIQWFWK AVLLMDAEKR IRLLQFVTGT SRVPMNGFAE LYGSNGPQLF TIEQWGSPEK LPRAHTCFNR LDLPPYETFE DLREKLLMAV ENAQGFEGVD
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Kreuzreaktivität
- Human, Maus, Ratte
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Produktmerkmale
- Polyclonal Antibodies
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Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 836-955 of human NEDD4L (NP_056092.2).
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Isotyp
- IgG
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Applikationshinweise
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
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Andere Bezeichnung
- NEDD4L
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Hintergrund
- This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.,NEDD4L,NEDD4-2,NEDD4.2,PVNH7,RSP5,hNEDD4-2,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,NEDD4L
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Molekulargewicht
- 96-111 kDa
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Gen-ID
- 23327
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UniProt
- Q96PU5
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Pathways
- Negative Regulation of Transporter Activity
Target
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