MLKL Antikörper

Produktnummer ABIN6143883

Der Kaninchen Polyklonal Anti-MLKL-Antikörper wurde für WB, IHC und IF validiert. Er ist geeignet, MLKL in Proben von Maus zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für MLKL Antikörper (ABIN6143883)

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MLKL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-MLKL Antikörper

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant protein of mouse MLKL

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-MLKL Antikörper (ABIN6143883)

Qin, Yang, Huang, Du, Mai, Xiao, Lü: "Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia." in: Pharmacological research, Vol. 133, pp. 218-235, (2018) (PubMed).

Zhang, Lyu, Liu, Lv, Chang, Rubinsky: "Molecular and histological study on the effects of non-thermal irreversible electroporation on the liver." in: Biochemical and biophysical research communications, Vol. 500, Issue 3, pp. 665-670, (2018) (PubMed).

Huang, Zheng, Wang, Chen, He, Zhang, Xu, Zhao, Shi, Wang, Zhu, Han: "The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process." in: Molecular and cellular biology, Vol. 37, Issue 5, (2017) (PubMed).

Details zu MLKL

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Andere Bezeichnung: MLKL

Hintergrund: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.,MLKL,hMLKL,Signal Transduction,Kinase,MLKL

Molekulargewicht: 53 kDa/54 kDa

Gen-ID: 74568

UniProt: Q9D2Y4