Caspase 7 Antikörper

Produktnummer ABIN614356

Dieser Maus Monoklonal Antikörper detektiert spezifisch Caspase 7 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Affe, Schwein, Hund, Kaninchen, Hamster und Schaf.

Kurzübersicht für Caspase 7 Antikörper (ABIN614356)

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Reaktivität: Human, Maus, Ratte, Affe, Schwein, Hund, Kaninchen, Hamster, Schaf

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Caspase 7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 07-01-11

Produktdetails anti-Caspase 7 Antikörper

Spezifität: Detects an ~37 kDa protein, corresponding to the apparent molecular mass of the Caspase-7 on SDS-PAGE Immunoblots, in samples from Human, Mouse, Rat, Monkey, Dog, Sheep, Rabbit, Pig and Hamster origins. This antibody recognizes the unprocessed pro-caspase-7 (p35), caspase-7 lacking the short amino- terminal pro domain (32 kDa) and the fully processed Caspase-7 (p19) in apoptotic cell extracts.

Kreuzreaktivität (Details): Species reactivity (expected):Canine, Hamster, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep.
Species reactivity (tested):Human.

Aufreinigung: Protein G Chromatography.

Immunogen: Recombinant Human CASP7.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.4 mg/mL

Buffer: 10 mM Sodium Phosphate, pH 7.2, 50 mM Sodium Chloride with 0.1 mM PMSF

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Caspase 7

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Andere Bezeichnung: Caspase-7

Hintergrund: Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis, initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse.Synonyms: Apoptotic protease Mch-3, CASP-7, CASP7, CMH-1, ICE-like apoptotic protease 3, MCH3

Gen-ID: 840

NCBI Accession: NP_001218

UniProt: P55210

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity