IL12RB2 Antikörper (AA 420-620)

Produktnummer ABIN6142303

Dieses Anti-IL12RB2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IL12RB2 in WB. Geeignet für Human.

Kurzübersicht für IL12RB2 Antikörper (AA 420-620) (ABIN6142303)

Target: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL12RB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IL12RB2 Antikörper

Bindungsspezifität: AA 420-620

Sequenz: GLLAPRQVSA NSEGMDNILV TWQPPRKDPS AVQEYVVEWR ELHPGGDTQV PLNWLRSRPY NVSALISENI KSYICYEIRV YALSGDQGGC SSILGNSKHK APLSGPHINA ITEEKGSILI SWNSIPVQEQ MGCLLHYRIY WKERDSNSQP QLCEIPYRVS QNSHPINSLQ PRVTYVLWMT ALTAAGESSH GNEREFCLQG K

Kreuzreaktivität: Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 420-620 of human IL12RB2 (NP_001550.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu IL12RB2

Target: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Andere Bezeichnung: IL12RB2

Hintergrund: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.,IL12RB2,Cancer,Tumor immunology,Immunology & Inflammation,Cytokines,Interleukins,Cell Intrinsic Innate Immunity Signaling Pathway,IL12RB2

Molekulargewicht: 74 kDa/87 kDa/97 kDa

Gen-ID: 3595

UniProt: Q99665

Pathways: JAK-STAT Signalweg