IFI27 Antikörper (AA 1-100)

Produktnummer ABIN6142164

Der Kaninchen Polyklonal Anti-IFI27-Antikörper wurde für WB validiert. Er ist geeignet, IFI27 in Proben von Human zu detektieren.

Kurzübersicht für IFI27 Antikörper (AA 1-100) (ABIN6142164)

Target: IFI27 (Interferon, alpha-Inducible Protein 27 (IFI27))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFI27 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IFI27 Antikörper

Bindungsspezifität: AA 1-100

Sequenz: MEASALTSSA VTSVAKVVRV ASGSAVVLPL ARIATVVIGG VVAVPMVLSA MGFTAAGIAS SSIAAKMMSA AAIANGGGVA SGSLVATLQS LGATGLSGLT

Kreuzreaktivität: Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IFI27 (NP_005523.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu IFI27

Target: IFI27 (Interferon, alpha-Inducible Protein 27 (IFI27))

Andere Bezeichnung: IFI27

Hintergrund: Probable adapter protein involved in different biological processes. Part of the signaling pathways that lead to apoptosis. Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. Also functions in TNFSF10-induced apoptosis. May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors. May thereby play a role in the vascular response to injury (By similarity. In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV. May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A.,IFI27,FAM14D,ISG12,ISG12A,P27,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,IFI27

Molekulargewicht: 11 kDa

Gen-ID: 3429

UniProt: P40305

Pathways: Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagie