FZR1 Antikörper (AA 224-493)

Produktnummer ABIN6140852

Der Kaninchen Polyklonal Anti-FZR1-Antikörper wurde für WB und IF validiert. Er ist geeignet, FZR1 in Proben von Human zu detektieren.

Kurzübersicht für FZR1 Antikörper (AA 224-493) (ABIN6140852)

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-FZR1 Antikörper

Bindungsspezifität: AA 224-493

Sequenz: DLSVEGDSVT SVGWSERGNL VAVGTHKGFV QIWDAAAGKK LSMLEGHTAR VGALAWNAEQ LSSGSRDRMI LQRDIRTPPL QSERRLQGHR QEVCGLKWST DHQLLASGGN DNKLLVWNHS SLSPVQQYTE HLAAVKAIAW SPHQHGLLAS GGGTADRCIR FWNTLTGQPL QCIDTGSQVC NLAWSKHANE LVSTHGYSQN QILVWKYPSL TQVAKLTGHS YRVLYLAMSP DGEAIVTGAG DETLRFWNVF SKTRSTKESV SVLNLFTRIR

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 224-493 of human FZR1 (NP_057347.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FZR1

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Andere Bezeichnung: FZR1

Hintergrund: Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ over error-free, RBBP8-mediated homologous recombination (HR.,FZR1,CDC20C,CDH1,FZR,FZR2,HCDH,HCDH1,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,FZR1

Molekulargewicht: 44 kDa/54 kDa/55 kDa

Gen-ID: 51343

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA