FLT1 Antikörper (AA 20-300)

Produktnummer ABIN6140687

Dieses Anti-FLT1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FLT1 in WB und IHC. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für FLT1 Antikörper (AA 20-300) (ABIN6140687)

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FLT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-FLT1 Antikörper

Bindungsspezifität: AA 20-300

Sequenz: LTGSSSGSKL KDPELSLKGT QHIMQAGQTL HLQCRGEAAH KWSLPEMVSK ESERLSITKS ACGRNGKQFC STLTLNTAQA NHTGFYSCKY LAVPTSKKKE TESAIYIFIS DTGRPFVEMY SEIPEIIHMT EGRELVIPCR VTSPNITVTL KKFPLDTLIP DGKRIIWDSR KGFIISNATY KEIGLLTCEA TVNGHLYKTN YLTHRQTNTI IDVQISTPRP VKLLRGHTLV LNCTATTPLN TRVQMTWSYP DEKNKRASVR RRIDQSNSHA NIFYSVLTID K

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human VEGFR1 (NP_001153392.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-FLT1 Antikörper (ABIN6140687)

Huang, Rehman, Lan, Qiu, Zhang, Iqbal, Luo, Mehmood, Zhang, Li: "Tibial dyschondroplasia is highly associated with suppression of tibial angiogenesis through regulating the HIF-1α/VEGF/VEGFR signaling pathway in chickens." in: Scientific reports, Vol. 7, Issue 1, pp. 9089, (2017) (PubMed).

Details zu FLT1

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Andere Bezeichnung: FLT1

Hintergrund: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.,FLT,FLT-1,VEGFR-1,VEGFR1,FLT1,Cancer,Invasion and Metastasis,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Growth factor,VEGF,VEGF Receptors,Endocrine & Metabolism,Cardiovascular,Angiogenesis,Angiogenic growth factors,Hypoxia,FLT1

Molekulargewicht: 39 kDa/41 kDa/52- 82 kDa/150 kDa

Gen-ID: 2321

UniProt: P17948

Pathways: RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals