DERL1 Antikörper (AA 182-251)

Produktnummer ABIN6139538

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DERL1 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für DERL1 Antikörper (AA 182-251) (ABIN6139538)

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DERL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DERL1 Antikörper

Bindungsspezifität: AA 182-251

Sequenz: LYFFLMFRYP MDLGGRNFLS TPQFLYRWLP SRRGGVSGFG VPPASMRRAA DQNGGGGRHN WGQGFRLGDQ

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 182-251 of human DERL1 (NP_077271.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu DERL1

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Andere Bezeichnung: DERL1

Hintergrund: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.,DERL1,DER-1,DER1,derlin-1,Signal Transduction,Neuroscience,Neurodegenerative Diseases,DERL1

Molekulargewicht: 26 kDa/28 kDa

Gen-ID: 79139

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling