COCH Antikörper (AA 20-260)

Produktnummer ABIN6138819

Dieses Anti-COCH-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von COCH in IHC und IF. Geeignet für Human.

Kurzübersicht für COCH Antikörper (AA 20-260) (ABIN6138819)

Target: COCH (Cochlin (COCH))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COCH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-COCH Antikörper

Bindungsspezifität: AA 20-260

Sequenz: GPAGSEGAAP IAITCFTRGL DIRKEKADVL CPGGCPLEEF SVYGNIVYAS VSSICGAAVH RGVISNSGGP VRVYSLPGRE NYSSVDANGI QSQMLSRWSA SFTVTKGKSS TQEATGQAVS TAHPPTGKRL KKTPEKKTGN KDCKADIAFL IDGSFNIGQR RFNLQKNFVG KVALMLGIGT EGPHVGLVQA SEHPKIEFYL KNFTSAKDVL FAIKEVGFRG GNSNTGKALK HTAQKFFTVD A

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human COCH (NP_001128530.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC,1:50 - 1:100,IF,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu COCH

Target: COCH (Cochlin (COCH))

Andere Bezeichnung: COCH

Hintergrund: The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.,COCH,COCH-5B2,COCH5B2,DFNA9,cochlin,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Neuroscience,COCH

Molekulargewicht: 53 kDa/59 kDa

Gen-ID: 1690

UniProt: O43405

Pathways: Sensory Perception of Sound